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All raw sequence data were deposited to NCBI SRA database with free public access. The following are the accession numbers: Human THP1 transcriptome RNAseq data: PRJNA601651; Porcine proximal colon tissue transcriptome data: PRJNA601460; Porcine proximal colon content 16S rRNA gene sequences: PRJNA601338; Mouse gut 16S rRNA gene sequences: PRJNA601328; Microbiome Standard and NDT: PRJNA601657. In addition, the raw data for untargeted metabolome analysis of porcine proximal colon contents are freely accessible at the Mendeley data ( ). The raw spectral data for mouse metabolome analysis are freely available at The feature and OTU tables can be downloaded at
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